Median PSA failure-free survival was 72 months (95% CI 41–72 months), while median metastasis-free survival was not reached. Nine patients (13%) developed metastatic castration-resistant disease and died of advanced prostate cancer. Thirty patients (43%) experienced biochemical failure after salvage radiotherapy and 16 patients (23%) experienced metastatic relapse. 5-year PSA failure- and metastasis-free survival rate was 56.9% and 76.9%, respectively. Forty-seven (68%) patients received androgen deprivation therapy (ADT). Thirty-six patients (52.2%) received CFR, 66 Gy in 33 fractions, 2 Gy per fraction, and 33 patients (47.8%) received HFR, 52.5 Gy in 20 fractions, 2.63 Gy per fraction. Sixty-nine patients who had persistent PSA (≥ 0.1 ng/mL) after prostatectomy were identified. Early and late toxicity was assessed using Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. Cox regression analysis was performed to test association of fractionation regimen and other clinical factors with treatment outcomes. ![]() PSA failure-free and metastasis-free survival were calculated using Kaplan–Meier method. Between May 2012 and December 2016, 147 patients received salvage postprostatectomy radiotherapy. Single institution retrospective chart review was performed after Institutional Review Board approval. Herein we report outcomes for conventionally fractionated (CFR) and hypofractionated radiotherapy (HFR) in patients with persistent postprostatectomy PSA who received salvage radiotherapy to prostate bed. Additionally, patients with persistent PSA after prostatectomy may have aggressive disease and respond less well on standard salvage treatment. ![]() Hypofractionated post-prostatectomy radiotherapy is emerging practice, however with no randomized evidence so far to support it’s use.
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![]() Gul'dan knows the Eye is here, but Tol Barad is huge and overrun. Nagaz says: Jergosh and the others didn't make it? How.convenient.Īllaris Narassin says: It matters not. Still, your timing could have been better. You have the Book of Medivh? I expected Jergosh, but you will do. Those fools were weak! We are better off without them!Īllaris Narassin says: Ah, reinforcements at last. You come upon an Orc and what appears to be an elf of some sort.Īllaris Narassin yells: Insolent orc! You should have awaited my arrival! You hear the bickering of two people and follow that. Find a group of Shadow Council then you will know you are heading in the right direction. Upon arriving in Tol Barad, you quickly can see it is infested with demons. Speak with Calydus and then head for Tol Barad. With it you will tear this world asunder and usher in the age of the Legion! Remember: Our masters do not take kindly to failure. To you will be given the glory of wielding the Scepter of Sargeras. Accomplish these tasks and there will be a place for you at my side. He is tasked with retrieving the Eye of Dalaran. Do this with the utmost speed, then make your way back to aid Allaris in Tol Barad. The Book of Medivh was given to the necromancers there long ago, and it is time we take it back. Gather all true supporters of our cause and go to Scholomance. If you know of any skilled warlocks interested in joining us, now is the time to call them into service. It is time for you to come out of hiding and return to the fold. I may not be the Gul'dan you once knew, but be assured that I represent everything he worked for.and more. Letter from Gul'dan: Jergosh, The Burning Legion has returned, and now is the time for the Shadow Council to be reformed. The related quest is The Tome of Blighted Implements and the description of the Scepter of Sargeras is: More artifact videos can be found on our YouTube Artifact Acquisition Playlist. Tortured + Season 11 PvP | Scepter + Tier 5 | Necrotic + Tier 10 | Empowered + Tier 6 | Fel Infused + Tier 4īelow is the questline for Destruction Warlock to acquire Scepter of Sargeras. ![]() You can also save and share an Outfit with this artifact. The other tints can still be unlocked if you finished the Mage Tower Artifact Challenge during Legion.Īrtifact weapons and order halls drew their inspiration from past iconic tier sets, so here are some transmog ideas for each artifact style. Note: The basic tint of the challenge appearance is unobtainable as of Battle for Azeroth prepatch. Guise of the Darkener - Unlocked through the Mage Tower Artifact Challenge, Feltotem's Fall. All of these tints can be previewed on the Appearance tab of the Artifact Calculator or the Legion Dressing Room.Īcquisition: The Burning Jewel of Sargeras, which unlocks the Legionterror hidden appearance, is obtained from summoned bosses in Dreadscar Rift (the Warlock Order Hall) via Demonic Offering This will be your primary weapon in Legion, allowing you to customize its appearance with numerous styles and tints.Įach spec's weapon has 6 styles, which can come in 4 color variations. This overview covers the basics of the Destruction Warlock artifact weapon, Scepter of Sargeras. ![]() Naruto describes the feeling of being alone in Naruto Shippuden Source: YouTube Because it is human nature to disagree now and then. We tend to disagree on the slightest of inconvenience that is posed our way and that is enough to begin the fight. It is bound to happen because we as humans will not be satisfied always. And small fights like these lead to war, where revenge is the ultimate driving force. The reason to start a fight can be any, be it religion, caste, resources, land, and even the pettiest of issues one can think of. War will never cease to exist… reasons can be thought up after the fact… Human nature pursues strife.” “Religion, ideology, resources, land, spite, love or just because… No matter how pathetic the reason, it’s enough to start war. Writer: Shin Yoshida, Katsuhiko Chiba, Yasuyuki Suzuki.Paine shares a great life lesson in Naruto Shippuden Source: Fiction Horizon What is real is the fact that each day we have the chance to become a little better than yesterday and just like that we live a beautiful life. If we consider ourselves to be the best, we create an illusion around us that isn’t real. And that very fact makes him open to changes and improvisations. “You need to accept the fact that you’re not the best and have all the will to strive to be better than anyone you face.” Roronoa Zoro emphasizes becoming better always in One Piece Source: CBR So take that risk of your heart fears and be ready to change your life forever! 36. Until that time we do not step out of our comfort zone, nothing will come easy and the future will be dull. ![]() And changes take place when we take risks and do not fear them. Growth in life only takes place when we are open to changes. “If you don’t take risks, you can’t create a future!” Luffy highlights the importance of taking risks in One Piece Source: Beta Justice always favors the ones who win through their hard work and persistence. But in the end, the one who is victorious dictates what is wrong and what is right. Sometimes we fight with our fears and challenges, sometimes we have to stand against the people in the world. “Those who stand at the top determine what’s wrong and what’s right! This very place is neutral ground! Justice will prevail, you say? But, of course, it will! Whoever wins this war becomes justice!”
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Pros And Cons Of The Hands-Free Male Masturbator What Is an Automatic Hands Free Male Masturbator?Īn automatic hands free male masturbator is a type of sex toy designed to give you hands-free stimulation to help you reach orgasm. ![]() That's because the formula is so rigid and predictable, and yet they're still endlessly repeatable. But funny knock knock jokes? They're almost an art form in and of themselves. Who's there? Gorilla.When it comes to the best jokes for kids, puns can be funny. Who's there? Cantaloupe! Cantaloupe who? Cantaloupe to Vegas, our parents would get mad! Lettuce who? Lettuce in, it's cold out here! Turnip who? Turnip the volume, I love this song! It's taking too long for you to open the door! Icing who? Icing so loud, the neighbors can hear! Bacon who? Bacon some cookies in there? It smells delicious! Gouda who? Gouda knock-knock jokes, don't you think? 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CanvaĬanva is a photo editor, colour palette tool, font combination picker, learning resource, and photo collage maker. This online graphic design software for beginners has a drag and drop format that makes it easy for anyone to create stunning visuals. Canva has a huge range of templates for everything from Facebook covers and Etsy shop icons to wine labels and gift certificates. Next time you need to create a flyer or pamphlet, business card, brochure, or social media graphic and you don’t want to hire a graphic designer or spend hours learning Photoshop, consider one of the following websites.Īll you have to do is register, select one of 1000’s of templates, customise and click “Download” and viola! Here are our top picks of free and user-friendly graphic design websites and apps: 01. 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